Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 31 Mar 2004

Friedlich Avi L, Lee Joo-Yong, van Groen Thomas, Cherny Robert A, Volitakis Irene, Cole Toby B, Palmiter Richard D, Koh Jae-Young, Bush Ashley I

Abstract excerpt

Cerebral amyloid angiopathy (CAA) is common in Alzheimer's disease (AD) and may contribute to dementia and cerebral hemorrhage. Parenchymal beta-amyloid deposition is dependent on the activity of zinc transporter 3 (ZnT3), a neocortical synaptic vesicle membrane protein that causes enrichment of exchangeable Zn2+ in the vesicle, which is externalized on neurotransmission. However, the contribution of zinc to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Vessels
Share to Cation Transport Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cerebral Amyloid Angiopathy

Share to Copper

Share to Neocortex

Share to Organ Specificity

Share to Synapses

Source

Open in PubMed Open full text

Identifiers

PMID: 15056725
DOI: 10.1523/JNEUROSCI.0297-04.2004
PMCID: PMC6730042

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease.PMID 15056725Read ↗

Alteration of the cerebral zinc pool in a mouse model of Alzheimer disease.Semantic proximity Read ↗

Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer's disease?Semantic proximity Read ↗

Elevation of zinc transporter ZnT3 protein in the cerebellar cortex of the AbetaPP/PS1 transgenic mouse.Semantic proximity Read ↗

Genetic analysis of the neuronal and ubiquitous AP-3 adaptor complexes reveals divergent functions in brain.Semantic proximity Read ↗

Serum Zinc Levels and in Vivo Beta-Amyloid Deposition in the Human BrainSemantic proximity Read ↗

Disruption of zinc transporter ZnT3 transcriptional activity and synaptic vesicular zinc in the brain of Huntington’s disease transgenic mouseSemantic proximity Read ↗

Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc.Semantic proximity Read ↗

Histochemically reactive zinc in plaques of the Swedish mutant beta-amyloid precursor protein transgenic mice.Semantic proximity Read ↗

Glia and zinc in ageing and Alzheimerâ€™s disease: a mechanism for cognitive decline?Semantic proximity Read ↗

Seizures and neuronal damage in mice lacking vesicular zinc.Semantic proximity Read ↗

Zinc released from metallothionein-iii may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injury.Semantic proximity Read ↗

Vesicular Zinc Modulates Cell Proliferation and Survival in the Developing HippocampusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.