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Article

Alterations of Zinc Transporter Proteins ZnT‐1, ZnT‐4 and ZnT‐6 in Preclinical Alzheimer's Disease Brain

9 Apr 2009

Abstract excerpt

Our previous studies demonstrate alterations of zinc (Zn) transporter proteins ZnT-1, ZnT-4 and ZnT-6 in vulnerable brain regions of subjects with mild cognitive impairment (MCI), and early and late stage Alzheimer's disease (AD), suggesting disruptions of Zn homeostasis may play a role in the pathogenesis of AD. A preclinical stage of AD (PCAD) has been described in which subjects show no overt clinical...

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PMID: 19371353
DOI: 10.1111/j.1750-3639.2009.00283.x

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