Article
The loss of Hoxa5 function causes estrous acyclicity and ovarian epithelial inclusion cysts.
Endocrinology - 1 Mar 2012
Gendronneau Gaëlle, Boucherat Olivier, Aubin Josée, Lemieux Margot, Jeannotte Lucie
Abstract excerpt
Hox genes encode transcription factors that play essential roles during embryo morphogenesis and organogenesis. Expression of several Hox members persists at the adult age, indicating a wide spectrum of action from embryonic to postnatal life. In the present study, we reported that in adult mice, the Hoxa5 gene shows a dynamic expression profile in the ovary that depends on the estrous cycle, the gestational...
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