Article

Loss of ASPM Disrupts Female Folliculogenesis in Mice

2021-08-09

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>The abnormal spindle-like, microcephaly-associated (<italic>ASPM</italic>) gene is a causative gene of autosomal recessive primary microcephaly (MCPH) 5 in humans, which is characterized by a reduction in brain volume. It was previously reported that truncated ASPM proteins in transgenic mice caused major defects in the germline, a severe reduction in ovary weig...

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Literature Corpus work: ac4a1182-f9e8-558e-81a5-91bc2cefeef6
DOI: 10.21203/rs.3.rs-783456/v1

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