Article
The role of polymorphisms at position 89 in the HIV-1 protease gene in the development of drug resistance to HIV-1 protease inhibitors.
The Journal of antimicrobial chemotherapy - 1 Apr 2012
Martinez-Cajas Jorge L, Wainberg Mark A, Oliveira Maureen, Asahchop Eugene L, Doualla-Bell Florence, Lisovsky Irene, Moisi Daniela, Mendelson Ella, Grossman Zehava, Brenner Bluma G
Abstract excerpt
OBJECTIVES: Relatively little is known about the development of resistance to protease inhibitors (PIs) in non-B subtypes. In subtype B viruses, L89 is commonly found at position 89 in the HIV protease (PR) gene, whereas M89 is commonly observed as a polymorphism in other subtypes. We compared the frequencies of substitutions at position 89 in PR in tissue culture selections and in clinical databases of PI-naive...
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