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Article

Genetic barrier for attachment inhibitor BMS-626529 resistance in HIV-1 B and non-B subtypes.

The Journal of antimicrobial chemotherapy - 1 Jan 2015

Fofana Djeneba B, Charpentier Charlotte, Maïga Almoustapha I, Lambert-Niclot Sidonie, Sayon Sophie, Désiré Nathalie, Simon Anne, Yazdanpanah Yazdan, Katlama Christine, Descamps Diane, Calvez Vincent, Marcelin Anne-Geneviève, Soulié Cathia

Abstract excerpt

OBJECTIVES: The genetic barrier (defined as the number of genetic transitions/transversions needed to produce a resistance mutation) can differ between HIV-1 subtypes. The genetic barrier for the new attachment inhibitor BMS-626529 was evaluated in five HIV-1 subtypes. METHODS: Nine substitutions associated with BMS-626529 resistance at seven amino acid positions (116, 204, 375, 426, 434, 475 and 506) were...

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Identifiers

PMID: 25270328
DOI: 10.1093/jac/dku360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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