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Article

Impact of HIV-1 protease mutations A71V/T and T74S on M89I/V-mediated protease inhibitor resistance in subtype G isolates.

The Journal of antimicrobial chemotherapy - 1 Jun 2008

Gonzalez Luis M F, Santos André F, Abecasis Ana B, Van Laethem Kristel, Soares Esmeralda A, Deforche Koen, Tanuri Amilcar, Camacho Ricardo, Vandamme Anne-Mieke, Soares Marcelo A

Abstract excerpt

OBJECTIVES: Non-B human immunodeficiency virus (HIV)-1 subtypes possess several amino acid signatures in the viral protease that distinguish them from subtype B, some of which are reported as secondary drug-related mutations. We have previously shown a strong statistical interdependency of residues 71, 89 and 90 in subtype G, but the impact of substitutions on protease inhibitor (PI) resistance is unknown....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18356151
DOI: 10.1093/jac/dkn099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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