Article
Experimental Sey mouse chimeras reveal the developmental deficiencies of Pax6-null granule cells in the postnatal cerebellum.
Developmental biology - 1 Mar 2011
Swanson Douglas J, Goldowitz Dan
Abstract excerpt
Pax6 has been implicated in cerebellar granule cell development, however the neonatal lethality of the Sey/Sey mutant has precluded a more detailed study of this late developing neuronal type. In this study we use experimental mouse chimeras made from wildtype and Pax6-null embryos to circumvent early lethality and assess the developmental potential of mutant cells in the construction of the cerebellum. We have...
Topics
- Animals
- Animals, Newborn
- Cell Differentiation
- Cell Movement
- Cerebellum
- Chimera
- Eye Proteins
- Female
- Homeodomain Proteins
- Ki-67 Antigen
- Mice
- Mice, Inbred BALB C
- Mice, Inbred ICR
- Mice, Neurologic Mutants
- Neurons
- PAX6 Transcription Factor
- Paired Box Transcription Factors
- Phenotype