Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neuronal differentiation and developmental characteristics in the dentate gyrus of staggerer mutant mice.

BMB reports - 1 Feb 2010

Yi Sun Shin, Hwang In Koo, Shin Jae Hoon, Baek Sung Hee, Yoon Yeo Sung, Seong Je Kyung

Abstract excerpt

Homozygous staggerer (RORa(sg/sg)) mice showed a severe ataxia caused by cerebellum degeneration. Decreased and dysfunctional Rora is a main cause of this neurologic phenotype. The phenotype of staggerer mice has been well known in cerebellum. However, there has been rarely reported about cerebrum even though of staggerer is expressed in merely cerebellum but hippocampus, thalamus, cortex, and olfactory bulb. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dentate Gyrus
Share to Doublecortin Domain Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Doublecortin Protein

Share to Ki-67 Antigen

Share to Mice, Neurologic Mutants

Share to Microtubule-Associated Proteins

Share to Neurons

Share to Neuropeptides

Source

Identifiers

PMID: 20193131
DOI: 10.5483/bmbrep.2010.43.2.122

Genes

DCX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neuronal differentiation and developmental characteristics in the dentate gyrus of staggerer mutant mice.PMID 20193131Read ↗

Progressive atrophy of cerebellar Purkinje cell dendrites during aging of the heterozygous staggerer mouse (Rora(+/sg)).Semantic proximity Read ↗

Cerebellar Purkinje cell loss during life span of the heterozygous staggerer mouse (Rora(+)/Rora(sg)) is gender-related.Semantic proximity Read ↗

Presence of calbindin D28K and GAD67 mRNAs in both orthotopic and ectopic Purkinje cells of staggerer mice suggests that staggerer acts after the onset of cytodifferentiation.Semantic proximity Read ↗

Age-related phenotypes in the staggerer mouse expand the RORalpha nuclear receptor's role beyond the cerebellum.Semantic proximity Read ↗

Cell loss in the inferior olive of the staggerer mutant mouse is an indirect effect of the gene.Semantic proximity Read ↗

A comparative study of Purkinje cells in two RORalpha gene mutant mice: staggerer and RORalpha(-/-).Semantic proximity Read ↗

Orphan nuclear receptor ROR alpha-deficient mice display the cerebellar defects of staggerer.Semantic proximity Read ↗

Purkinje cell loss in heterozygous staggerer mutant mice during aging.Semantic proximity Read ↗

RORalpha, a pivotal nuclear receptor for Purkinje neuron survival and differentiation: from development to ageing.Semantic proximity Read ↗

Early behavioral development of mice is affected by staggerer mutation as soon as postnatal day three.Semantic proximity Read ↗

staggerer phenotype in retinoid-related orphan receptor alpha-deficient mice.Semantic proximity Read ↗

Alteration of cerebellar neurotropin messenger ribonucleic acids and the lack of thyroid hormone receptor augmentation by staggerer-type retinoic acid receptor-related orphan receptor-alpha mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.