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Article

Purkinje cell loss in heterozygous staggerer mutant mice during aging.

Brain research. Developmental brain research - 2 Jan 1997

Hadj-Sahraoui N, Frederic F, Zanjani H, Herrup K, Delhaye-Bouchaud N, Mariani J

Abstract excerpt

The cerebellum on the heterozygous (+/sg) staggerer mutant mouse has recently been proposed as a model system in which to study the genetic contribution to the normal process of central nervous system aging since there is significant loss of neurons from 3 to 12 months of age (Shojaeian-Zanjani, H., Mariani, J., Delhaye-Bouchaud, N., and Herrup, K. (1992) Dev. Brain Res., 67, 153-160). In the current study we...

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PMID: 9027398
DOI: 10.1016/s0165-3806(96)00153-8

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