Article
Prevalence of Apolipoprotein E Polymorphisms in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Elderly: A Northern Greece Study.
Neuro-degenerative diseases - 1 Jan 2018
Tsolaki Anthoula C, Gatzima Olympia, Daniilidou Makrina, Lazarou Eutuxia, Bamidis Panagiotis D, Verykouki Eleni, Iakovidou-Kritsi Zafiroura, Tsolaki Magda
Abstract excerpt
BACKGROUND: Apolipoprotein E ε4 allele (APOEε4) is a major genetic risk factor for Alzheimer's disease (AD). APOEε4 carriers have a higher risk of cognitive impairment and AD in a gene dose-dependent manner. The above notion is investigated in the Greek population. METHODS: A sample of 1,703 subjects (967 AD patients, 576 mild cognitive impairment [MCI] and 160 Healthy Elderly), was genotyped for APOE from 2008...
Topics
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Apolipoproteins E
- Cognition Disorders
- Cognitive Dysfunction
- Female
- Gene Frequency
- Genotype
- Greece