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Article

Association of C3435T single-nucleotide polymorphism of MDR1 gene with breast cancer in an Iranian population.

DNA and cell biology - 1 May 2009

Tatari Farnoosh, Salek Roham, Mosaffa Fatemeh, Khedri Azam, Behravan Javad

Abstract excerpt

The human multidrug resistance gene 1 (MDR1) encodes a plasma membrane, P-glycoprotein (Pgp), which functions as the transmembrane efflux pump for various structurally unrelated anticancer agents and toxins. Polymorphisms in the MDR1 gene may have an impact on the expression and function of Pgp, thereby influencing the susceptibility to various diseases, including cancer. Recently, a silent C3435T polymorphism in...

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Identifiers

PMID: 19388849
DOI: 10.1089/dna.2008.0826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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