Article
IL-1β (-511T/C) gene polymorphism not IL-1β (+3953T/C) and LT-α (+252A/G) gene variants confers susceptibility to visceral leishmaniasis.
Molecular biology reports - 1 Jun 2012
Moravej Ali, Rasouli Manoochehr, Kalani Mehdi, Asaei Sadaf, Kiany Simin, Najafipour Sohrab, Koohpayeh Amin, Abdollahi Abbas
Abstract excerpt
Lymphotoxin-α (LT-α) and interleukin-1beta (IL-1β) are proinflammatory cytokines playing important roles in immunity against Leishmania infection and the outcome of the disease. As cytokine productions are under the genetic control, this study tried to find any probable relationship between these cytokine gene polymorphisms and the susceptibility to visceral leishmaniasis in Iranian pediatric patients....
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