Article
Association of interleukin-18 gene variants with susceptibility to visceral leishmaniasis in Iranian population.
Molecular biology reports - 1 Jun 2013
Moravej Ali, Rasouli Manoochehr, Asaei Sadaf, Kalani Mehdi, Mansoori Yaser
Abstract excerpt
Host resistance to Leishmania infection is mediated by cellular immune responses leading to macrophage activation and parasite killing. Interleukin-18 (IL-18) known as interferon-γ (IFN-γ) inducing factor, stimulates IFN-γ production by T cells. Taking into account the important role of IL-18 in the defense against visceral leishmaniasis (VL) and the known effect of IL-18 gene polymorphisms on its production, the...
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