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Unmodified Histone H3K4 and DNA-Dependent Protein Kinase Recruit Autoimmune Regulator to Target Genes

7 Feb 2012

Abstract excerpt

Autoimmune regulator (AIRE) directs the expression of otherwise tissue-restricted antigens (TRAs) in medullary thymic epithelial cells, allowing their presentation to developing T cells, which leads to central tolerance. We addressed the conundrum of how AIRE is recruited to these otherwise silent genes in cells. Our studies confirmed that interactions between AIRE and the unmodified histone H3K4 (H3K4me0) are...

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PMID: 22310661
DOI: 10.1128/mcb.06359-11

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Unmodified Histone H3K4 and DNA-Dependent Protein Kinase Recruit Autoimmune Regulator to Target GenesPMID 22310661Read ↗

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AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity.Semantic proximity Read ↗

DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity.Semantic proximity Read ↗

Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.Semantic proximity Read ↗

Functional Domains of Autoimmune Regulator (AIRE) Modulate INS-VNTR Transcription in Human Thymic Epithelial Cells.Semantic proximity Read ↗

AIRE in context: Leveraging chromatin plasticity to trigger ectopic gene expression*Semantic proximity Read ↗

Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells.Semantic proximity Read ↗

High-Resolution Transcriptional Impact of AIRE: Effects of Pathogenic Variants p.Arg257Ter, p.Cys311Tyr, and Polygenic Risk Variant p.Arg471CysSemantic proximity Read ↗

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