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Article

Global relevance of Aire binding to hypomethylated lysine-4 of histone-3.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2010

Koh Andrew S, Kingston Robert E, Benoist Christophe, Mathis Diane

Abstract excerpt

Aire promotes the ectopic expression of a repertoire of peripheral-tissue antigens (PTAs) in thymic medullary epithelial cells (MECs) to mediate deletional tolerance and thereby prevent autoimmunity. Binding of hypomethylated histone 3 (H3)-tails by Aire's plant homeodomain (PHD) finger is essential for Aire function in cultured cell models, prompting speculation that Aire-PHD:H3-tail interactions underlie...

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Share to AIRE Protein
Share to Epithelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immune Tolerance

Share to Lysine

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Source

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Identifiers

PMID: 20615959
DOI: 10.1073/pnas.1004436107
PMCID: PMC2919944

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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