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Article

AIRE activated tissue specific genes have histone modifications associated with inactive chromatin

10 Sept 2009

Abstract excerpt

The Autoimmune Regulator (AIRE) protein is expressed in thymic medullary epithelial cells, where it promotes the ectopic expression of tissue-restricted antigens needed for efficient negative selection of developing thymocytes. Mutations in AIRE cause APECED syndrome, which is characterized by a breakdown of self-tolerance. The molecular mechanism by which AIRE increases the expression of a variety of different...

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PMID: 19744957
DOI: 10.1093/hmg/ddp433

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