Article
Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions.
Neuron - 4 Aug 2005
Verstreken Patrik, Ly Cindy V, Venken Koen J T, Koh Tong-Wey, Zhou Yi, Bellen Hugo J
Abstract excerpt
In a forward screen for genes affecting neurotransmission in Drosophila, we identified mutations in dynamin-related protein (drp1). DRP1 is required for proper cellular distribution of mitochondria, and in mutant neurons, mitochondria are largely absent from synapses, thus providing a genetic tool to assess the role of mitochondria at synapses. Although resting Ca2+ is elevated at drp1 NMJs, basal synaptic...
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