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Article

In vivo synaptic recovery following optogenetic hyperstimulation.

Proceedings of the National Academy of Sciences of the United States of America - 6 Aug 2013

Kittelmann Maike, Liewald Jana F, Hegermann Jan, Schultheis Christian, Brauner Martin, Steuer Costa Wagner, Wabnig Sebastian, Eimer Stefan, Gottschalk Alexander

Abstract excerpt

Local recycling of synaptic vesicles (SVs) allows neurons to sustain transmitter release. Extreme activity (e.g., during seizure) may exhaust synaptic transmission and, in vitro, induces bulk endocytosis to recover SV membrane and proteins; how this occurs in animals is unknown. Following optogenetic hyperstimulation of Caenorhabditis elegans motoneurons, we analyzed synaptic recovery by time-resolved behavioral,...

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Identifiers

PMID: 23878262
DOI: 10.1073/pnas.1305679110
PMCID: PMC3740886

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