Article
VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission.
Nature neuroscience - 11 Mar 2012
Raingo Jesica, Khvotchev Mikhail, Liu Pei, Darios Frederic, Li Ying C, Ramirez Denise M O, Adachi Megumi, Lemieux Philippe, Toth Katalin, Davletov Bazbek, Kavalali Ege T
Abstract excerpt
Synaptic vesicles in the brain harbor several soluble N-ethylmaleimide-sensitive-factor attachment protein receptor (SNARE) proteins. With the exception of synaptobrevin2, or VAMP2 (syb2), which is directly involved in vesicle fusion, the role of these SNAREs in neurotransmission is unclear. Here we show that in mice syb2 drives rapid Ca(2+)-dependent synchronous neurotransmission, whereas the structurally...
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