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Helicobacter pylori AddAB helicase‐nuclease and RecA promote recombination‐related DNA repair and survival during stomach colonization

20 Jun 2008

Abstract excerpt

Helicobacter pylori colonization of the human stomach is characterized by profound disease-causing inflammation. Bacterial proteins that detoxify reactive oxygen species or recognize damaged DNA adducts promote infection, suggesting that H. pylori requires DNA damage repair for successful in vivo colonization. The molecular mechanisms of repair remain unknown. We identified homologues of the AddAB class of...

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PMID: 18573180
DOI: 10.1111/j.1365-2958.2008.06336.x

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