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Article

The structural basis of the kinetic mechanism of a gap-filling X-family DNA polymerase that binds Mg(2+)-dNTP before binding to DNA.

Journal of molecular biology - 30 Mar 2012

Nakane Shuhei, Ishikawa Hirohito, Nakagawa Noriko, Kuramitsu Seiki, Masui Ryoji

Abstract excerpt

DNA with single-nucleotide (1-nt) gaps can arise during various DNA processing events. These lesions are repaired by X-family DNA polymerases (PolXs) with high gap-filling activity. Some PolXs can bind productively to dNTPs in the absence of DNA and fill these 1-nt gaps. Although PolXs have a crucial role in efficient gap filling, currently, little is known of the kinetic and structural details of their...

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PMID: 22306405
DOI: 10.1016/j.jmb.2012.01.025

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