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Article

In silico studies of the African swine fever virus DNA polymerase X support an induced-fit mechanism.

Biophysical journal - 1 Jan 2006

Sampoli Benítez Benedetta A, Arora Karunesh, Schlick Tamar

Abstract excerpt

The African swine fever virus DNA polymerase X (pol X), a member of the X family of DNA polymerases, is thought to be involved in base excision repair. Kinetics data indicate that pol X catalyzes DNA polymerization with low fidelity, suggesting a role in viral mutagenesis. Though pol X lacks the fingers domain that binds the DNA in other members of the X family, it binds DNA tightly. To help interpret details of...

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Identifiers

PMID: 16214865
DOI: 10.1529/biophysj.105.071944
PMCID: PMC1367036

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