Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Template strand scrunching during DNA gap repair synthesis by human polymerase lambda.

Nature structural & molecular biology - 1 Sept 2009

Garcia-Diaz Miguel, Bebenek Katarzyna, Larrea Andres A, Havener Jody M, Perera Lalith, Krahn Joseph M, Pedersen Lars C, Ramsden Dale A, Kunkel Thomas A

Abstract excerpt

Family X polymerases such as DNA polymerase lambda (Pol lambda) are well suited for filling short gaps during DNA repair because they simultaneously bind both the 5' and 3' ends of short gaps. DNA binding and gap filling are well characterized for 1-nucleotide (nt) gaps, but the location of yet-t...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biocatalysis
Share to Conserved Sequence
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Polymerase beta

Share to DNA Repair

Share to Nucleic Acid Conformation

Share to Sequence Alignment

Share to Templates, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 19701199
DOI: 10.1038/nsmb.1654
PMCID: PMC2767187

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19701199-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Template strand scrunching during DNA gap repair synthesis by human polymerase lambda.PMID 19701199Read ↗

Promiscuous mismatch extension by human DNA polymerase lambdaSemantic proximity Read ↗

Efficiency and fidelity of human DNA polymerases λ and β during gap-filling DNA synthesis.Semantic proximity Read ↗

Tolerating DNA damage by repriming: Gap filling in the spotlightSemantic proximity Read ↗

Sustained active site rigidity during synthesis by human DNA polymerase μ.Semantic proximity Read ↗

Pol V-Mediated Translesion Synthesis Elicits Localized Untargeted Mutagenesis during Post-replicative Gap RepairSemantic proximity Read ↗

Human polymerase kappa uses a template-slippage deletion mechanism, but can realign the slipped strands to favour base substitution mutations over deletions.Semantic proximity Read ↗

Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta.Semantic proximity Read ↗

Human polymerase theta helicase positions DNA microhomologies for double-strand break repairSemantic proximity Read ↗

DNA pol λ's extraordinary ability to stabilize misaligned DNA.Semantic proximity Read ↗

DNA replication fidelity.Semantic proximity Read ↗

Translesion DNA synthesis: little fingers teach tolerance.Semantic proximity Read ↗

Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase delta.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.