Article
Overexpression of mouse TTF-2 gene causes cleft palate.
Journal of cellular and molecular medicine - 1 Oct 2012
Meng Tian, Shi Jia-Yu, Wu Min, Wang Yan, Li Ling, Liu Yan, Zheng Qian, Huang Lei, Shi Bing
Abstract excerpt
In humans, mutations of the gene encoding for thyroid transcription factor-2 (TTF-2 or FOXE1) result in Bamforth syndrome. Bamforth syndrome is characterized by agenesis, cleft palate, spiky hair and choanal atresia. TTF-2 null mice (TTF-2(-/-) ) also exhibit cleft palate, suggesting its involvement in the palatogenesis. However, the molecular pathology and genetic regulation by TTF2 remain largely unknown. In...
Topics
- Animals
- Cleft Palate
- Epithelium
- Female
- Forkhead Transcription Factors
- Genotype
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Palate
- Promoter Regions, Genetic
- Proteins
- RNA, Messenger