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Article

Overexpression of mouse TTF-2 gene causes cleft palate.

Journal of cellular and molecular medicine - 1 Oct 2012

Meng Tian, Shi Jia-Yu, Wu Min, Wang Yan, Li Ling, Liu Yan, Zheng Qian, Huang Lei, Shi Bing

Abstract excerpt

In humans, mutations of the gene encoding for thyroid transcription factor-2 (TTF-2 or FOXE1) result in Bamforth syndrome. Bamforth syndrome is characterized by agenesis, cleft palate, spiky hair and choanal atresia. TTF-2 null mice (TTF-2(-/-) ) also exhibit cleft palate, suggesting its involvement in the palatogenesis. However, the molecular pathology and genetic regulation by TTF2 remain largely unknown. In...

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Source

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Identifiers

PMID: 22304410
DOI: 10.1111/j.1582-4934.2012.01546.x
PMCID: PMC3823429

Genes

FOXE1
TTF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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