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Article

Anomalous incisor morphology indicates tissue-specific roles for Tfap2a and Tfap2b in tooth development.

Developmental biology - 1 Apr 2021

Woodruff Emily D, Gutierrez Galaxy C, Van Otterloo Eric, Williams Trevor, Cohn Martin J

Abstract excerpt

Mice possess two types of teeth that differ in their cusp patterns; incisors have one cusp and molars have multiple cusps. The patterning of these two types of teeth relies on fine-tuning of the reciprocal molecular signaling between dental epithelial and mesenchymal tissues during embryonic development. The AP-2 transcription factors, particularly Tfap2a and Tfap2b, are essential components of such...

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Identifiers

PMID: 33460639
DOI: 10.1016/j.ydbio.2020.12.017
PMCID: PMC8018193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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