Article

Differential DNA damage response to WRN inhibition identifies a targetable vulnerability in ARID1A-mutated cancers

2025-05-09

Abstract excerpt

ARID1A, a key subunit of the SWI/SNF chromatin remodeling complex, is frequently mutated in cancers. However, effective clinical treatments for patients with this mutation are limited, highlighting a demand for new therapeutic strategies. Here, we establish Werner syndrome ATP-dependent helicase (WRN) as a critical vulnerability target in ARID1A-mutated cancers. Upon genetic and pharmacological inhibition of WRN,...

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Literature Corpus work: 2694339b-57fe-53f0-aa0e-b6a451c053a6
DOI: 10.1101/2025.05.04.652100

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