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Article

Identifying quantitative trait loci affecting resistance to congenital hypothyroidism in 129/SvJcl strain mice.

PloS one - 1 Jan 2012

Hosoda Yayoi, Sasaki Nobuya, Kameda Yayoi, Torigoe Daisuke, Agui Takashi

Abstract excerpt

Tyrosylprotein sulfotransferase 2 (TPST2) is one of the enzymes responsible for tyrosine O-sulfation and catalyzes the sulfation of the specific tyrosine residue of thyroid stimulating hormone receptor (TSHR). Since this modification is indispensable for the activation of TSH signaling, a non-functional TPST2 mutation (Tpst2(grt)) in DW/J-grt mice leads to congenital hypothyroidism (CH) characterized by severe...

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Source

Open in PubMed Open full text

Identifiers

PMID: 22299049
DOI: 10.1371/journal.pone.0031035
PMCID: PMC3267771

Genes

TPST2
TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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