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Article

Hearing impairment in hypothyroid dwarf mice caused by mutations of the thyroid peroxidase gene.

Journal of the Association for Research in Otolaryngology : JARO - 1 Feb 2014

Johnson Kenneth R, Gagnon Leona H, Longo-Guess Chantal M, Harris Belinda S, Chang Bo

Abstract excerpt

Thyroid hormone (TH) is essential for proper cochlear development and function, and TH deficiencies cause variable hearing impairment in humans and mice. Thyroid peroxidase (TPO) catalyzes key reactions in TH synthesis, and TPO mutations have been found to underlie many cases of congenital hypothyroidism in human patients. In contrast, only a single mutation of the mouse TPO gene has been reported previously...

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Share to Auditory Threshold
Share to Cochlea

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Iodide Peroxidase

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Source

Open in PubMed Open full text

Identifiers

PMID: 24297261
DOI: 10.1007/s10162-013-0427-7
PMCID: PMC3901854

Genes

TPO
ABR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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