Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypothyroid phenotype of the Tpst2 mutant mouse is dependent upon genetic background.

Biomedical research (Tokyo, Japan) - 1 Jun 2010

Hosoda Yayoi, Sasaki Nobuya, Agui Takashi

Abstract excerpt

DW/J-grt is a congenital hypothyroid mouse model that is characterized by growth retardation, significantly lowered T3 and T4 levels, and severe thyroid hypoplasia related to TSH hyporesponsiveness. Previously, we identified the point mutation of the Tpst2 gene in DW/J-grt mice that causes a decrease in the enzymatic activity, and demonstrated that the Tpst2 transgene rescues the mutant phenotypes both in vitro...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hypothyroidism
Share to Mice
Share to Mice, Mutant Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Point Mutation

Share to Sulfotransferases

Source

Identifiers

PMID: 20622471
DOI: 10.2220/biomedres.31.207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypothyroid phenotype of the Tpst2 mutant mouse is dependent upon genetic background.PMID 20622471Read ↗

Identifying quantitative trait loci affecting resistance to congenital hypothyroidism in 129/SvJcl strain mice.Semantic proximity Read ↗

A mutation in Tpst2 encoding tyrosylprotein sulfotransferase causes dwarfism associated with hypothyroidism.Semantic proximity Read ↗

Hearing impairment in hypothyroid dwarf mice caused by mutations of the thyroid peroxidase gene.Semantic proximity Read ↗

Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone.Semantic proximity Read ↗

Compensatory role of thyroid hormone receptor (TR) alpha 1 in resistance to thyroid hormone: study in mice with a targeted mutation in the TR beta gene and deficient in TR alpha 1.Semantic proximity Read ↗

A mouse model demonstrates a multigenic origin of congenital hypothyroidism.Semantic proximity Read ↗

Identification of a point mutation in the thyrotropin receptor of the hyt/hyt hypothyroid mouse.Semantic proximity Read ↗

Marked potentiation of the dominant negative action of a mutant thyroid hormone receptor beta in mice by the ablation of one wild-type beta allele.Semantic proximity Read ↗

A Missense Mutation G2320R in the Thyroglobulin Gene Causes Non-goitrous Congenital Primary Hypothyroidism in the WIC-<i>rdw</i>RatSemantic proximity Read ↗

A targeted dominant negative mutation of the thyroid hormone alpha 1 receptor causes increased mortality, infertility, and dwarfism in mice.Semantic proximity Read ↗

Use of a new model of transgenic mice to clarify the respective functions of thyroid hormone receptors in vivo.Semantic proximity Read ↗

Congenital hypothyroidism, dwarfism, and hearing impairment caused by a missense mutation in the mouse dual oxidase 2 gene, Duox2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.