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Article

Identification of a point mutation in the thyrotropin receptor of the hyt/hyt hypothyroid mouse.

1 Feb 1994

Abstract excerpt

The hyt/hyt hypothyroid mouse has an autosomal recessive, fetal-onset, severe hypothyroidism related to TSH hyporesponsiveness and associated with elevated TSH. Our previous work has suggested that the hypothyroidism and TSH hyporesponsiveness may result from a mutation in the hyt/hyt TSH receptor (TSHr) of the thyroid gland. Based on DNA sequencing of the entire coding region of the TSHr gene from the wild-type...

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Identifiers

PMID: 8170469
DOI: 10.1210/mend.8.2.8170469

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