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Article

Aberrant chondrocyte hypertrophy and activation of β-catenin signaling precede joint ankylosis in ank/ank mice.

The Journal of rheumatology - 1 Mar 2012

Las Heras Facundo, Pritzker Kenneth P H, So Anthony, Tsui Hing Wo, Chiu Basil, Inman Robert D, Tsui Florence W L

Abstract excerpt

OBJECTIVE: We assessed the role of Ank in the maintenance of postnatal articular cartilage using the ank/ank mouse (mice homozygous for progressive ankylosis). METHODS: We analyzed ank/ank mice and wild-type littermates (8, 12, and 18 weeks old). Sections from decalcified, paraffin-embedded joints were stained with hematoxylin and eosin. Articular chondrocyte size and cartilage thickness were determined using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22298904
DOI: 10.3899/jrheum.110971

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