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Article

Investigation of the effects of DNA repair gene polymorphisms on the risk of colorectal cancer.

Mutagenesis - 1 Mar 2012

Tomlinson Ian P M, Houlston Richard S, Montgomery Grant W, Sieber Oliver M, Dunlop Malcolm G

Abstract excerpt

Despite their prime candidate status, polymorphisms near genes involved in DNA repair or in other functions related to genome stability have been conspicuously under-represented in the significant associations reported from genome-wide association studies (GWAS) of cancer susceptibility. In this study, we assessed a set of single-nucleotide polymorphisms (SNPs) near 157 DNA repair genes in three colorectal cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22294770
DOI: 10.1093/mutage/ger070
PMCID: PMC4610049

Genes

CHEK2
MLH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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