Meta-analysis of mismatch repair polymorphisms within the cogent consortium for colorectal cancer susceptibility.

doi:10.1371/journal.pone.0072091

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Article

Meta-analysis of mismatch repair polymorphisms within the cogent consortium for colorectal cancer susceptibility.

PloS one - 1 Jan 2013

Picelli Simone, Lorenzo Bermejo Justo, Chang-Claude Jenny, Hoffmeister Michael, Fernández-Rozadilla Ceres, Carracedo Angel, Castells Antoni, Castellví-Bel Sergi, Naccarati Alessio, Pardini Barbara, Vodickova Ludmila, Müller Heiko, Talseth-Palmer Bente A, Stibbard Geoffrey, Peterlongo Paolo, Nici Carmela, Veneroni Silvia, Li Li, Casey Graham, Tenesa Albert, Farrington Susan M, Tomlinson Ian, Moreno Victor, van Wezel Tom, Wijnen Juul, Dunlop Malcolm, Radice Paolo, Scott Rodney J, Vodicka Pavel, Ruiz-Ponte Clara, Brenner Hermann, Buch Stephan, Völzke Henry, Hampe Jochen, Schafmayer Clemens, Lindblom Annika

Abstract excerpt

In the last four years, Genome-Wide Association Studies (GWAS) have identified sixteen low-penetrance polymorphisms on fourteen different loci associated with colorectal cancer (CRC). Due to the low risks conferred by known common variants, most of the 35% broad-sense heritability estimated by twin studies remains unexplained. Recently our group performed a case-control study for eight Single Nucleotide...

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Identifiers

PMID: 24039736
DOI: 10.1371/journal.pone.0072091
PMCID: PMC3765450

Genes

MUTYH

Variants

rs3219489

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