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Article

Murine retroviral bone marrow transplantation models for the study of human myeloproliferative disorders.

Current protocols in pharmacology - 1 Dec 2008

Gavrilescu L Cristina, Van Etten Richard A

Abstract excerpt

Human myeloproliferative diseases are common hematologic disorders characterized by clonal overproduction of maturing myeloid or erythroid cells, often caused by expression of a mutant, dysregulated tyrosine kinase (TK). These diseases can be accurately modeled in laboratory mice by the retroviral transfer of a mutant TK gene into murine hematopoietic stem and progenitor cells, followed by transplantation of...

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Identifiers

PMID: 22294220
DOI: 10.1002/0471141755.ph1410s43

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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