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Article

Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm.

Journal of visualized experiments : JoVE - 22 Dec 2016

Nguyen Thanh Kim, Morse Sarah J, Fleischman Angela G

Abstract excerpt

Transduction-transplantation is a quick and efficient way to model human hematologic malignancies in mice. This technique results in expression of the gene of interest in hematopoietic cells and can be used to study the gene's role in normal and/or malignant hematopoiesis. This protocol provides a detailed description on how to perform transduction-transplantation using calreticulin (CALR) mutations recently...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28060252
DOI: 10.3791/54624
PMCID: PMC5226441

Genes

CALR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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