Article
Genotype-phenotype correlation of cytochrome P450 2C9 polymorphism in Indian National Capital Region.
European journal of drug metabolism and pharmacokinetics - 1 Dec 2013
Varshney Ekta, Saha Nilanjan, Tandon Monika, Shrivastava Vikesh, Ali Shakir
Abstract excerpt
Identification of polymorphism of cytochrome P450 2C9 (CYP2C9) enzymes in different ethnic populations is important to understand the differences in clinical responses to drugs. This study determines the CYP2C9 genetic polymorphism in Indian National Capital Region and correlates the phenotype-genotype. Losartan (25 mg) was administered to 107 volunteers to assess CYP2C9 activity, and, on the basis of results,...
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