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Article

Whole genome gene copy number profiling of gastric cancer identifies PAK1 and KRAS gene amplification as therapy targets.

Genes, chromosomes & cancer - 1 Nov 2014

Qian Ziliang, Zhu Guanshan, Tang Lili, Wang Mei, Zhang Lianhai, Fu Jiangang, Huang Chunlei, Fan Shuqiong, Sun Yun, Lv Jing, Dong Hua, Gao Beirong, Su Xinying, Yu Dehua, Zang Jie, Zhang Xiaolin, Ji Jiafu, Ji Qunsheng

Abstract excerpt

Gastric cancer is the second leading cause of death from cancer worldwide, with an approximately 20% 5-year survival rate. To identify molecular subtypes associated with the clinical prognosis, in addition to genetic aberrations for potential targeted therapeutics, we conducted a comprehensive whole-genome analysis of 131 Chinese gastric cancer tissue specimens using whole-genome array comparative genomic...

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Source

Identifiers

PMID: 24935174
DOI: 10.1002/gcc.22196

Genes

KRAS
PAK1
ABCC4
CTSB
ERBB2
FGFR2
MET
PRKCI
STARD13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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