A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.

doi:10.1371/journal.pgen.1002480

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Article

A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.

PLoS genetics - 1 Jan 2012

Naitza Silvia, Porcu Eleonora, Steri Maristella, Taub Dennis D, Mulas Antonella, Xiao Xiang, Strait James, Dei Mariano, Lai Sandra, Busonero Fabio, Maschio Andrea, Usala Gianluca, Zoledziewska Magdalena, Sidore Carlo, Zara Ilenia, Pitzalis Maristella, Loi Alessia, Virdis Francesca, Piras Roberta, Deidda Francesca, Whalen Michael B, Crisponi Laura, Concas Antonio, Podda Carlo, Uzzau Sergio, Scheet Paul, Longo Dan L, Lakatta Edward, Abecasis Gonçalo R, Cao Antonio, Schlessinger David, Uda Manuela, Sanna Serena, Cucca Francesco

Abstract excerpt

Identifying the genes that influence levels of pro-inflammatory molecules can help to elucidate the mechanisms underlying this process. We first conducted a two-stage genome-wide association scan (GWAS) for the key inflammatory biomarkers Interleukin-6 (IL-6), the general measure of inflammation...

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Identifiers

PMID: 22291609
DOI: 10.1371/journal.pgen.1002480
PMCID: PMC3266885

Genes

CRP
SPPL3
ABO
AIRE
CADM3
CCR2
HBB
ICOSLG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22291609-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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