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Article

MHC susceptibility genes to IgA deficiency are located in different regions on different HLA haplotypes.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2002

De la Concha Emilio G, Fernandez-Arquero Miguel, Gual Lorena, Vigil Patricia, Martinez Alfonso, Urcelay Elena, Ferreira Antonio, Garcia-Rodriguez Maria C, Fontan Gumersindo

Abstract excerpt

Familial predisposition to IgA deficiency (IgAD) suggests that genetic factors influence susceptibility. Most studies support a polygenic inheritance with a susceptibility locus (designated IGAD1) in the MHC, but its exact location is still controversial. This study aimed to map the predisposing IGAD1 locus (or loci) within the MHC by investigating the pattern of association of the disease with several markers in...

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Source

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PMID: 12370403
DOI: 10.4049/jimmunol.169.8.4637

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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