Article
Dietary restriction and fasting arrest B and T cell development and increase mature B and T cell numbers in bone marrow.
PloS one - 1 Jan 2014
Shushimita Shushimita, de Bruijn Marjolein J W, de Bruin Ron W F, IJzermans Jan N M, Hendriks Rudi W, Dor Frank J M F
Abstract excerpt
Dietary restriction (DR) delays ageing and extends life span. Both long- and short-term DR, as well as short-term fasting provide robust protection against many "neuronal and surgery related damaging phenomena" such as Parkinson's disease and ischemia-reperfusion injury. The exact mechanism behind this phenomenon has not yet been elucidated. Its anti-inflammatory actions prompted us to thoroughly investigate the...
Topics
- Animals
- B-Lymphocyte Subsets
- Body Weight
- Bone Marrow Cells
- Caloric Restriction
- Cell Count
- Cell Cycle Checkpoints
- Cell Differentiation
- Fasting
- Immunophenotyping
- Lymphoid Tissue
- Male
- Mice
- Phenotype