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Twist-1 Induces Ezh2 Recruitment Regulating Histone Methylation along the <i>Ink4A/Arf</i> Locus in Mesenchymal Stem Cells

31 Jan 2012

Abstract excerpt

The main impairment to tissue maintenance during aging is the reduced capacity for stem cell self-renewal over time due to senescence, the irreversible block in proliferation. We have previously described that the basic helix-loop-helix (bHLH) transcription factor Twist-1 can greatly enhance the life span of bone marrow-derived mesenchymal stem/stromal cells (MSCs). In the present study, we show that Twist-1...

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PMID: 22290439
DOI: 10.1128/mcb.06315-11

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