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Epithelial–mesenchymal transition and cancer stemness: the Twist1–Bmi1 connection

15 Sept 2011

Abstract excerpt

EMT (epithelial-mesenchymal transition), a major mechanism of cancer metastasis, is a process that generates cells with stem-like properties. These stem-like cells in tumours are described as cancer stem cells. The link between EMT and cancer stemness is well documented without detailed mechanistic proof. Bmi1 belongs to the PRC1 (polycomb repressive complex 1) maintaining self-renewal and stemness together with...

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PMID: 21919891
DOI: 10.1042/bsr20100114

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