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Article

Mutational profiling of acute myeloid leukemia with normal cytogenetics in Brazilian patients: the value of next-generation sequencing for genomic classification.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Dec 2017

de Noronha Thiago Rodrigo, Mitne-Neto Miguel, Chauffaille Maria de Lourdes

Abstract excerpt

Karyotype (KT) aberrations are important prognostic factors for acute myeloid leukemia (AML); however, around 50% of cases present normal results. Single nucleotide polymorphism array can detect chromosomal gains, losses or uniparental disomy that are invisible to KT, thus improving patients' risk assessment. However, when both tests are normal, important driver mutations can be detected by the use of...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28923882
DOI: 10.1136/jim-2017-000566

Genes

DNMT3A
IDH1
IDH2
TET2
ASXL1
BRAF
CBL
FLT3
GATA2
JAK2
KIT
KRAS
NPM1
NRAS
PTPN11
RUNX1
TP53
WT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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