Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic suppression by aminoglycoside antibiotics of mutations blocking erythromycin biosynthesis in Saccharopolyspora erythraea.

Journal of bacteriology - 1 Nov 1990

Lewandowska-Skarbek M, Hutchinson C R

Abstract excerpt

The presence of a sublethal amount of apramycin, the aminoglycoside antibiotic used as a selectable marker in transformations of Saccharopolyspora erythraea with pKC505 and related plasmids, was found to suppress phenotypically the S. erythraea eryB25 and eryB26 mutations blocking erythromycin biosynthesis in this organism, probably by the effect of mistranslation.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Erythromycin
Share to Gram-Positive Bacteria

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Phenotype

Share to Suppression, Genetic

Share to Transformation, Bacterial

Source

Open in PubMed Open full text

Identifiers

PMID: 2228978
DOI: 10.1128/jb.172.11.6605-6606.1990
PMCID: PMC526855

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic suppression by aminoglycoside antibiotics of mutations blocking erythromycin biosynthesis in Saccharopolyspora erythraea.PMID 2228978Read ↗

Comparative genomics and transcriptional profiles of Saccharopolyspora erythraea NRRL 2338 and a classically improved erythromycin over-producing strain.Semantic proximity Read ↗

Mutation and cloning of eryG, the structural gene for erythromycin O-methyltransferase from Saccharopolyspora erythraea, and expression of eryG in Escherichia coli.Semantic proximity Read ↗

Application of In Vitro Transposon Mutagenesis to Erythromycin Strain Improvement in Saccharopolyspora erythraea.Semantic proximity Read ↗

Cloning of genes involved in erythromycin biosynthesis from Saccharopolyspora erythraea using a novel actinomycete-Escherichia coli cosmid.Semantic proximity Read ↗

Knocking out of tailoring genes eryK and eryG in an industrial erythromycin-producing strain of Saccharopolyspora erythraea leading to overproduction of erythromycin B, C and D at different conversion ratios.Semantic proximity Read ↗

Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea.Semantic proximity Read ↗

Genetic Modulation of the Overexpression of Tailoring Genes <i>eryK</i> and <i>eryG</i> Leading to the Improvement of Erythromycin A Purity and Production in <i>Saccharopolyspora erythraea</i> FermentationSemantic proximity Read ↗

[Use of protoplast fusion in the selection of erythromycin-producing strains of Saccharopolyspora erythraea].Semantic proximity Read ↗

[Isolation and characterization of Saccharopolyspora erythraea mutants, resistant to chloramphenicol].Semantic proximity Read ↗

An erythromycin process improvement using the diethyl methylmalonate-responsive (Dmr) phenotype of the Saccharopolyspora erythraea mutB strain.Semantic proximity Read ↗

[The isolation and characteristics of mutants of the Saccharopolyspora erythraea strain resistant to thiostrepton].Semantic proximity Read ↗

Minimal functional system required for expression of erythromycin resistance by msrA in Staphylococcus aureus RN4220.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.