Phenotypic suppression by aminoglycoside antibiotics of mutations blocking erythromycin biosynthesis in Saccharopolyspora erythraea.

doi:10.1128/jb.172.11.6605-6606.1990

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Article

Phenotypic suppression by aminoglycoside antibiotics of mutations blocking erythromycin biosynthesis in Saccharopolyspora erythraea.

Journal of bacteriology - 1 Nov 1990

Lewandowska-Skarbek M, Hutchinson C R

Abstract excerpt

The presence of a sublethal amount of apramycin, the aminoglycoside antibiotic used as a selectable marker in transformations of Saccharopolyspora erythraea with pKC505 and related plasmids, was found to suppress phenotypically the S. erythraea eryB25 and eryB26 mutations blocking erythromycin bi...

Topics

Anti-Bacterial Agents
Erythromycin
Gram-Positive Bacteria
Mutation
Nebramycin
Phenotype
Suppression, Genetic
Transformation, Bacterial

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