Genetic Modulation of the Overexpression of Tailoring Genes <i>eryK</i> and <i>eryG</i> Leading to the Improvement of Erythromycin A Purity and Production in <i>Saccharopolyspora erythraea</i> Fermentation

Abstract excerpt

Erythromycin A (Er-A) is the most potent and clinically important member in the Er family produced by Saccharopolyspora erythraea. Er-B and Er-C, which are biologically much less active and cause greater side effects than Er-A, serve as the intermediates for Er-A biosynthesis and impurities in fermentation processes of many industrial strains. In this study, systematical modulation of the amounts of tailoring...

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