Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea.

doi:10.1128/jb.172.5.2372-2383.1990

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Article

Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea.

Journal of bacteriology - 1 May 1990

Weber J M, Leung J O, Maine G T, Potenz R H, Paulus T J, DeWitt J P

Abstract excerpt

We used a series of gene disruptions and gene replacements to mutagenically characterize 30 kilobases of DNA in the erythromycin resistance gene (ermE) region of the Saccharopolyspora erythraea chromosome. Five previously undiscovered loci involved in the biosynthesis of erythromycin were found,...

Topics

Chromosomes, Bacterial
Drug Resistance, Microbial
Erythromycin
Escherichia coli
Genes, Bacterial
Genetic Linkage
Multigene Family
Mutation
Phenotype
Plasmids
Restriction Mapping
Streptomyces
Transformation, Bacterial

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