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Article

An erythromycin process improvement using the diethyl methylmalonate-responsive (Dmr) phenotype of the Saccharopolyspora erythraea mutB strain.

Applied microbiology and biotechnology - 1 Feb 2012

Weber J Mark, Cernota William H, Gonzalez Melissa C, Leach Benjamin I, Reeves Andrew R, Wesley Roy K

Abstract excerpt

The Saccharopolyspora erythraea mutB knockout strain, FL2281, having a block in the methylmalonyl-CoA mutase reaction, was found to carry a diethyl methylmalonate-responsive (Dmr) phenotype in an oil-based fermentation medium. The Dmr phenotype confers the ability to increase erythromycin A (erythromycin) production from 250-300% when the oil-based medium is supplemented with 15 mM levels of this solvent. Lower...

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Identifiers

PMID: 22048617
DOI: 10.1007/s00253-011-3650-3
PMCID: PMC3276693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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