Article
Comparative genomics and transcriptional profiles of Saccharopolyspora erythraea NRRL 2338 and a classically improved erythromycin over-producing strain.
Microbial cell factories - 8 Mar 2012
Peano Clelia, Talà Adelfia, Corti Giorgio, Pasanisi Daniela, Durante Miriana, Mita Giovanni, Bicciato Silvio, De Bellis Gianluca, Alifano Pietro
Abstract excerpt
BACKGROUND: The molecular mechanisms altered by the traditional mutation and screening approach during the improvement of antibiotic-producing microorganisms are still poorly understood although this information is essential to design rational strategies for industrial strain improvement. In this study, we applied comparative genomics to identify all genetic changes occurring during the development of an...
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