Article
MLH1, BRAF and p53 - searching for significant markers to predict evolution towards adenocarcinoma in colonic sessile serrated lesions.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie - 1 Jan 2000
Răduţă Diana, Dincă Octavian Marius, Micu Gianina Viorica, Nichita Luciana, Cioplea Mirela Daniela, Buşcă Radu Mihai, Ardeleanu Raluca, Mateescu Radu Bogdan, Benguş Andreea, Zurac Sabina Andrada, Popp Cristiana Gabriela, Vlădan George Cristian
Abstract excerpt
BACKGROUND AND AIM: Colonic serrated lesions are premalignant lesions, using an alternative malignization pathway, including multiple genetic and epigenetic alterations, as: mismatch repair deficiency due to MutL homolog 1 (MLH1) promoter methylation, tumor protein p53 (TP53) mutations, activating mutations of v-Raf murine sarcoma viral oncogene homolog B (BRAF) and Kirsten rat sarcoma viral oncogene homolog...
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